Cumin, Frederic: search on Z-Library

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1

Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors

Vulpetti, Anna, Randl, Stefan, Rüdisser, Simon, Ostermann, Nils, Erbel, Paul, Mac Sweeney, Aengus, Zoller, Thomas, Salem, Bahaa, Gerhartz, Bernd, Cumin, Frederic, Hommel, Ulrich, Dalvit, Claudio, Lort

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.94 MB

english, 2017

2

Evidence for a single active site in the human angiotensin I-converting enzyme from inhibitor binding studies with [3H] RU 44 403: Role of chloride

Frédéric Cumin, Véronique Vellaud, Pierre Corvol, François Alhenc-Gelas

Journal:

Biochemical and Biophysical Research Communications

Year:

1989

Language:

english

File:

PDF, 413 KB

english, 1989

3

The P1 N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin

Yasuchika Yamaguchi, Keith Menear, Nissim-Claude Cohen, Robert Mah, Frédéric Cumin, Christian Schnell, Jeanette M. Wood, Jürgen Maibaum

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 363 KB

english, 2009

4

Uncoupling of protein-3 induces an uncontrolled uncoupling of mitochondria after expression in muscle derived L6 cells

Danilo Guerini, Elisabetta Prati, Urvi Desai, Hans Peter Nick, Rolf Flammer, Stephan Grüninger, Frederic Cumin, Machael Kaleko, Sheila Connelly, Michele Chiesi

Journal:

Year:

2002

Language:

english

File:

PDF, 258 KB

english, 2002

5

Binding of a Tritiated Pepstatin Analog to Human Renin

Cumin, Frédéric, Nisato, Dino, Gagnol, Jean-Pierre, Corvol, Pierre

Journal:

Journal of Cardiovascular Pharmacology

Year:

1987

File:

PDF, 211 KB

1987

6

Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats

Wood, Jeanette M, Schnell, Christian R, Cumin, Frederic, Menard, Jo??l, Webb, Randy L

Journal:

Journal of Hypertension

Year:

2005

Language:

english

File:

PDF, 355 KB

english, 2005

7

Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D

Vulpetti, Anna, Ostermann, Nils, Randl, Stefan, Yoon, Taeyoung, Mac Sweeney, Aengus, Cumin, Frederic, Lorthiois, Edwige, Rüdisser, Simon, Erbel, Paul, Maibaum, Jürgen

Journal:

ACS Medicinal Chemistry Letters

Year:

2018

Language:

english

File:

PDF, 856 KB

english, 2018

8

A peptide leptin antagonist reduces food intake in rodents

Brunner, L, Whitebread, S, Leconte, I, Stricker-Krongrad, A, Cumin, Frederic, Chiesi, M, Levens, N

Journal:

International Journal of Obesity

Year:

1999

Language:

english

File:

PDF, 136 KB

english, 1999

9

Optical and structural proprieties of nc-Si:H prepared by argon diluted silane PECVD

Rachid Amrani, Frederic Pichot, Jean Podlecki, Alain Foucaran, Larbi Chahed, Yvan Cuminal

Journal:

Journal of Non-Crystalline Solids

Year:

2012

Language:

english

File:

PDF, 658 KB

english, 2012

10

Analysis of phenotypic consequences of renin gene polymorphism in Lyon rats

Kaiser, Michael, Vincent, Madeleine, Kenyon, Christopher J., Gomez-Sanchez, Celso E., Cumin, Frederic, Lodwick, David, Sassard, Jean, Samani, Nilesh J.

Journal:

Journal of Hypertension

Year:

1997

Language:

english

File:

PDF, 794 KB

english, 1997

11

Pharmacology of renin inhibitors and their application to the treatment of hypertension

Jeanette M. Wood, Frédéric Cumin, Jürgen Maibaum

Journal:

Pharmacology & Therapeutics

Year:

1994

Language:

english

File:

PDF, 1.47 MB

english, 1994

12

Renal actions of the angiotensin AT2 receptor ligands CGP 42112 and PD 123319 after blockade of the renin-angiotensin system

David Macari, Steven Whitebread, Frederic Cumin, Marc De Gasparo, Nigel Levens

Journal:

European Journal of Pharmacology

Year:

1994

Language:

english

File:

PDF, 981 KB

english, 1994

13

Discovery of highly potent and selective small-molecule reversible Factor D inhibitors demonstrating alternative complement pathway inhibition in vivo

Lorthiois, Edwige, Anderson, Karen, Vulpetti, Anna, Rogel, Olivier, Cumin, Frederic, Ostermann, Nils, Steinbacher, Stefan, Mac Sweeney, Aengus, Delgado, Omar, Liao, Sha-Mei, Randl, Stefan, Rüdisser, S

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 2.52 MB

english, 2017

14

Structural Modification of the P2‘ Position of 2,7-Dialkyl-Substituted 5( S )-Amino-4( S )-hydroxy-8-phenyl-octanecarboxamides: The Discovery of Aliskiren, a Potent Nonpeptide Human Renin Inhibitor Active after Once Daily Dosing in Marmosets

Maibaum, Jürgen, Stutz, Stefan, Göschke, Richard, Rigollier, Pascal, Yamaguchi, Yasuchika, Cumin, Frédéric, Rahuel, Joseph, Baum, Hans-Peter, Cohen, Nissim-Claude, Schnell, Christian R., Fuhrer, Walte

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 371 KB

english, 2007

15

trans-(3S,4S)-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part I: Prime site exploration using an amino linker

Lorthiois, Edwige, Cumin, Frederic, Ehrhardt, Claus, Kosaka, Takatoshi, Sellner, Holger, Ostermann, Nils, Francotte, Eric, Wagner, Trixie, Maibaum, Jürgen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 885 KB

english, 2015

16

Comparative enzymatic studies of human renin acting on pure natural or synthetic substrates

Frédéric Cumin, Dung Le-Nguyen, Bertrand Castro, Joël Menard, Pierre Corvol

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1987

Language:

english

File:

PDF, 724 KB

english, 1987

17

Plasma Leptin and Hypothalamic Neuropeptide Y and Galanin Levels in Long-Evans Rats with Marked Dietary Preferences

Beck, Bernard, Stricker-Krongrad, Alain, Burlet, Arlette, Cumin, Frederic, Burlet, Claude

Journal:

Nutritional Neuroscience

Year:

2001

Language:

english

File:

PDF, 1.04 MB

english, 2001

18

Scaled-up production of recombinant human renin in CHO cells for enzymatic and X-ray structure analysis

Fred A.M. Asselbergs, Joseph Rahuel, Frédéric Cumin, Christian Leist

Journal:

Journal of Biotechnology

Year:

1994

Language:

english

File:

PDF, 984 KB

english, 1994

19

Analysis by Immunocytochemistry and in situ Hybridization of Renin and Its mRNA in Kidney, Testis, Adrenal, and Pituitary of the Rat

Christian F. Deschepper, Synthia H. Mellon, Frédéric Cumin, John D. Baxter and William F. Ganong

Journal:

Proceedings of the National Academy of Sciences

Year:

1986

Language:

english

File:

PDF, 1.53 MB

english, 1986

20

trans-3,4-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part II: Prime site exploration using an oxygen linker

Sellner, Holger, Cottens, Sylvain, Cumin, Frédéric, Ehrhardt, Claus, Kosaka, Takatoshi, Lorthiois, Edwige, Ostermann, Nils, Webb, Randy L., Rigel, Dean F., Wagner, Trixie, Maibaum, Jürgen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.95 MB

english, 2015

21

Tissue Expression of Components of the Renin—Angiotensin System in Experimental Post-Infarction Heart Failure in Rats: Effects of Heart Failure and Angiotensin-Converting Enzyme Inhibitor Treatment

Kelly, Martin P., Kahr, OLE, Aalkjaer, Christian, Cumin, Frederic, Samani, Nilesh J

Journal:

Clinical Science

Year:

1997

Language:

english

File:

PDF, 1.41 MB

english, 1997

22

The Discovery of Novel Potent trans -3,4-Disubstituted Pyrrolidine Inhibitors of the Human Aspartic Protease Renin from in Silico Three-Dimensional (3D) Pharmacophore Searches

Lorthiois, Edwige, Breitenstein, Werner, Cumin, Frederic, Ehrhardt, Claus, Francotte, Eric, Jacoby, Edgar, Ostermann, Nils, Sellner, Holger, Kosaka, Takatoshi, Webb, Randy L., Rigel, Dean F., Hassiepe

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.18 MB

english, 2013

23

Differential Regulation of Intestinal and Liver Fatty Acid-Binding Proteins in Human Intestinal Cell line (Caco-2): Role of Collagen

Christian Darimont, Nathalie Gradoux, Frédéric Cumin, Hans-Peter Baum, Alain De Pover

Journal:

Experimental Cell Research

Year:

1998

Language:

english

File:

PDF, 257 KB

english, 1998

24

Modulation of human prorenin gene expression by antisense oligonucleotides in transfected CHO cells

Frederic CUMIN, Fred ASSELBERGS, Michèle LARTIGOT, Eduard FELDER

Journal:

Year:

1993

Language:

english

File:

PDF, 2.44 MB

english, 1993

25

A potent radiolabeled human renin inhibitor [3H]SR42128: enzymatic, kinetic, and binding studies to renin and other aspartic proteases

Cumin, Frederic, Nisato, Dino, Gagnol, Jean Pierre, Corvol, Pierre

Journal:

Year:

1987

Language:

english

File:

PDF, 864 KB

english, 1987

26

Structure of neprilysin in complex with the active metabolite of sacubitril

Schiering, Nikolaus, D’Arcy, Allan, Villard, Frederic, Ramage, Paul, Logel, Claude, Cumin, Frederic, Ksander, Gary M., Wiesmann, Christian, Karki, Rajeshri G., Mogi, Muneto

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 877 KB

english, 2016

27

Gastric acid secretion after blockade of angiotensin AT1 receptors in the Na+-depleted rat

Larry Chow, Katherine Zakrzewska, Marc De Gasparo, Frederic Cumin, Nigel Levens

Journal:

European Journal of Pharmacology

Year:

1995

Language:

english

File:

PDF, 1.17 MB

english, 1995

28

Oxidation pathways towards Si amorphous layers or nanocrystalline powders as Li-ion batteries anodes

Annou, Kamal, Pelosi, Mathilde, Gershinsky, Gregory, Favier, Frederic, Cuminal, Yvan, Tillard, Monique, Zitoun, David

Journal:

Materials for Renewable and Sustainable Energy

Year:

2014

Language:

english

File:

PDF, 1.36 MB

english, 2014

29

The Renin-Angiotensin System in the Rabbit Eye

RAMIREZ, MANUEL, DAVIDSON, ELIZABETH A., LUTTENAUER, LAURENT, ELENA, PIERRE-PAUL, CUMIN, FRÉDÉRIC, MATHIS, GEORG A., DE GASPARO, MARC

Journal:

Journal of Ocular Pharmacology and Therapeutics

Year:

1996

Language:

english

File:

PDF, 2.94 MB

english, 1996

30

Aspartic Proteases in Drug Discovery

Eder, Jorg, Hommel, Ulrich, Cumin, Frederic, Martoglio, Bruno, Gerhartz, Bernd

Journal:

Current Pharmaceutical Design

Year:

2007

Language:

english

File:

PDF, 398 KB

english, 2007

31

Bioactive hydroxyethylene dipeptide isosteres with hydrophobic (P3-P1)-moieties. A novel strategy towards small non-peptide renin inhibitors

Vittorio Rasetti, N.Claude Cohen, Heinrich Rüeger, Richard Göschke, Jürgen Maibaum, Frederic Cumin, Walter Fuhrer, Jeanette M. Wood

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 426 KB

english, 1996

32

1085-165 Aliskiren, a novel, orally effective nonpeptide renin inhibitor, lowers blood pressure after once-daily dosing in marmosets, rats and humans

Jeanette M Wood, Randy L Webb, Frederic Cumin, Christian R Schnell, Martin P Bedigian

Journal:

Journal of the American College of Cardiology

Year:

2004

Language:

english

File:

PDF, 124 KB

english, 2004

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